Effect of Golden nanoparticles and Domperidone on some hematological parameters in pregnant rabbits

Abstract

The present study aims to investigate the effects of golden nanoparticles (AuNPs) alone or with the administration of the emetic drug (domperidone) on some hematological parameters of pregnant rabbits. In this study, twenty pregnant rabbits, were collected and divided into four groups (n = 5 in each group) as follows: the control group allow to drink 1 ml / kg of distilled water orally, the G1 group received an injected dose (i.m) of 150µg / kg of AuNPs, while the G2 group was treated with 300 µg /kg of the domperidone. The combined group (G3) received both AuNPs injected and domperidone orally (150µg / kg and 300 µg /kg, respectively). Blood samples were taken from each animal at (0, 15, 30 and 40) days of experimental periods to test hematological parameters (WBC count, RBC count, hemoglobin level (HGB) and Hematocrit percentage (HCT), which were calculated by using hematology analyzer. The results of the study demonstrated that there is no significant difference in WBC, RBC counts, hemoglobin, and hematocrit levels between the AuNPs and domperidone groups and the Control and G3 groups. As well as, there is no effect between periods for each group in these parameters in blood of pregnant rabbits. Thus, it is concluded that injected of AuNPs has no toxic effect on blood, as well as, the domperidone has same effect on blood.